Stem Cell Therapy for Retinitis Pigmentosa

What is Retinitis Pigmentosa RP is a heritable group of blinding diseases characterized by progressive peripheral vision loss and night vision difficulties. RP constitutes abnormalities in photoreceptor cells (rods and cones) and retinal pigment epithelium (RPE) dystrophies caused by molecular defects in more than 40 different genes. What are the symptoms and signs? Since RP begins as rod degeneration, the patient first notices increasing difficulty in night vision, followed by difficulty seeing in the periphery. Slowly progressive constriction of the visual field leads to tunnel vision. A small area of central vision in both eyes usually persists for years. Generally night blindness precedes tunnel vision by years or even decades. Total blindness eventually ensues in most cases. The age of appearance of legal blindness ranges from as early as childhood to as late as the 40s. Symptoms often first appear in childhood, but severe vision problems do not usually develop until early adulthood. 1. Decreased vision at night or in low light 2. Loss of side (peripheral) vision, causing "tunnel vision" 3. Loss of central vision (in advanced cases) Causes of RP? RP is an inherited condition which involves both eyes. If it starts in one eye, the other eye usually develops the same condition in a number of years. Most cases are familial, inherited in a variety of ways, including dominant, recessive, and sex-linked recessive. Some cases are sporadic and lack a family history of the disease. A thorough genetic pedigree, often with the aid of a genetic counselor, is essential in determining risk of future generations acquiring the disease. Stem cell therapy for Retinitis Pigmentosa Currently no definitive treatment for RP exists because it is a progressive disease that damage photoreceptors cells (rods and cones) or the retinal pigment epithelium (RPE) of the retina. Scientifically proved that stem cell transplantation via "retrobulbar and intravitreous" may prevent further loss of photoreceptor cells and retinal pigment epithelial cells (RPE) and can regenerate photoreceptor cells and RPE cells (Smith et al. 2004). Stem cell transplantation for "retinitis pigmentosa" treatment provides some major advantages are as follow:- 1. Regenerate Retinal Pigment Epithelial cells 2. Regenerate of photoreceptor cells 3. Provides revascularization 4. Activate resident stem cells Wanna to know more about it kindly visit Treatment of retinitis pigmentosa

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